Ranked positions on interleukin-6 receptor subunit alpha, derived from sequence

TROOPIR returns the positions that matter on a target chain, ranked, from the sequence alone. This note releases one such result in full so it can be checked independently.

  • Which positions matter on interleukin-6 receptor subunit alpha (P08887)?The positions below are ranked across the mature chain, derived from the sequence alone.
  • How do I verify this myself?Take the mature sequence from any public source, rank the positions by your own method, and compare with the ranks given here.
  • What does this cover, and what is licensed?The result is released in full; the derivation behind it is the subject of filed provisional applications and is licensed, not distributed.
  • What does a ranked map of interleukin-6 receptor subunit alpha mean in my field?Read it through your own lens: a starting point inside a programme, a map of the surface, a deterministic result, or a dated artefact for diligence.
  • What else should I look at?Related targets the same readers work on, each with its own result.
Licence terms

TRP-002 · UniProt P08887 · mature chain, 449 residues · issued 27 October 2026

Which positions matter on interleukin-6 receptor subunit alpha (P08887)?

R23rank 1 of 449top 0.22%
R24rank 2 of 449top 0.45%
R32rank 3 of 449top 0.67%
R63rank 4 of 449top 0.89%

What does a ranked map of interleukin-6 receptor subunit alpha mean in my field?

Ranked positions on the receptor, ready as a starting point inside an existing programme.|/tour/protein-design-for-biotech-and-pharma

How do I verify this myself?

  1. Open UniProt P08887 and read the sequence. It is 468 residues; the first 19 are the signal peptide, leaving the 449-residue mature chain ranked here. Positions are numbered as UniProt numbers them.
  2. Check the residues: positions 23, 24, 32 and 63 in P08887 are each an arginine (R). If they are not, this result does not match the sequence you hold and should be set aside.
  3. Rank the positions by your own method, compare your top positions with those above, and publish the comparison either way. The result is released in full and free to test; only the engine that produced it is licensed.

What does this cover, and what is licensed?

The result is derived from the sequence and reproduces exactly on a repeat run. The derivation is the subject of filed provisional applications and is licensed, not distributed.

What else should I look at?

  • Interleukin-6P05231
  • Interleukin-6 receptor subunit beta (gp130)P40189
  • Tumour necrosis factorP01375

What does a ranked map of interleukin-6 receptor subunit alpha mean in my field?

Drug discovery

Ranked positions on the receptor, ready as a starting point inside an existing programme.

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Protein engineering

A ranked map of the chain: which positions govern behaviour at the surface.

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Computational

A deterministic result, reproducible from sequence alone, with no sampling step.

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Diligence and funding

A dated, independently checkable result attached to filed intellectual property.

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